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Fig. 6 | Journal of Neuroinflammation

Fig. 6

From: Spatial and temporal variation of routine parameters: pitfalls in the cerebrospinal fluid analysis in central nervous system infections

Fig. 6

Limitations of the Reiber–Felgenhauer nomograms in the absence of steady state—hypothetical cases. In each case the values used for the calculation of the quotients are given. A Seeming impairment of the blood–CSF barrier in a patient after rapid correction of an intravascular volume deficit of 33% (filled squares: albumin CSF 300 mg/l, serum 40,000 mg/l, IgG CSF 40 mg/l, serum 10,000 mg/l, IgA CSF 2 mg/l, serum 2000 mg/l, IgM CSF 1 mg/l, serum 2000 mg/l; filled reverse triangles: albumin CSF 300 mg/l, serum 26,700 mg/l, IgG CSF 40 mg/l, serum 6660 mg/l, IgA CSF 2 mg/l, serum 1330 mg/l, IgM CSF 1 mg/l, serum 1330 mg/l). B Seeming intrathecal antibody synthesis after removal of 75% of the intravenous immunoglobulins by immune absorption (before immunoadsorption—filled squares: albumin CSF 200 mg/l, serum 40,000 mg/l, IgG CSF 20 mg/l, serum 10,000 mg/l, IgA CSF 2 mg/l, serum 2000 mg/l, IgM CSF 1 mg/l, serum 2000 mg/l; after immunoadsorption—filled circles: albumin CSF 200 mg/l, serum 40,000 mg/l, IgG CSF 40 mg/l, serum 2500 mg/l, IgA CSF 2 mg/l, serum 500 mg/l, IgM CSF 1 mg/l, serum 500 mg/l). C Apparent disappearance of an intrathecal IgG synthesis after infusion of 120 g IgG (before IgG infusion—open circles: albumin CSF 200 mg/l, serum 40,000 mg/l, IgG CSF 40 mg/l, serum 10,000 mg/l, IgA CSF 2 mg/l, serum 2000 mg/l, IgM CSF 1 mg/l, serum 2000 mg/l; after IgG infusion—open squares: albumin CSF 200 mg/l, serum 40,000 mg/l, IgG CSF 40 mg/l, serum 30,000 mg/l, IgA CSF 2 mg/l, serum 2000 mg/l, IgM CSF 1 mg/l, serum 2000 mg/l). D Seeming increase in intrathecal IgG synthesis after infusion of 60 g albumin (before albumin infusion—open circles: albumin CSF 200 mg/l, serum 40,000 mg/l, IgG CSF 40 mg/l, serum 10,000 mg/l, IgA CSF 2 mg/l, serum 2000 mg/l, IgM CSF 1 mg/l, serum 2000 mg/l; after albumin infusion—open reverse triangles: albumin CSF 200 mg/l, serum 50,000 mg/l, IgG CSF 40 mg/l, serum 10,000 mg/l, IgA CSF 2 mg/l, serum 2000 mg/l, IgM CSF 1 mg/l, serum 2000 mg/l)

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