Fig. 3

Delay and/or reduction of inflammation- and DAM-associated genes in the ArcticC5aR1KO hippocampus. A Heatmap of selected genes in the hippocampus present in RNA cluster 6. Genes were clustered based on AD study findings and molecular functions. RNA-seq data (TPM) is row-mean normalized. B Gene ontology (GO) and pathway enrichment analyses of genes present in Rc6. C Heatmap of genes enriched in Phagosome pathway (mmu04145) in the hippocampus. Numbers in front of gene names correspond to protein they encode, as seen in D. D Representative diagram of the Phagosome pathway (mmu04145) with select protein encoded by genes present in the panel C heatmap highlighted in red. N = 4–10 mice/genotype/age