Fig. 5
From: Modulation of C5a–C5aR1 signaling alters the dynamics of AD progression
C5a overexpression leads to increase in expression of genes associated with synapse transmission and assembly in the hippocampus. A Heatmap of selected genes in the hippocampus present in RNA clusters 3 and 4. Genes were clustered based on biological processes. RNA-seq data (TPM) is row-mean normalized. B Gene ontology (GO) and pathway enrichment analyses of genes present in Rc6. C Representative diagram of the GABAergic synapse pathway with select genes present in the panel A heatmap highlighted in red. N = 4–10 mice/genotype/age