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Fig. 11 | Journal of Neuroinflammation

Fig. 11

From: A cannabidiol aminoquinone derivative activates the PP2A/B55α/HIF pathway and shows protective effects in a murine model of traumatic brain injury

Fig. 11

VCE-004.8 attenuates the expression of inflammatory cytokines in TBI. The mRNA expression for inflammatory markers in the pericontusional cortex (Il-1β, Il-6, Ccl2 and Il10) was quantified by qPCR and normalized versus Ppia at 24 h, 72 h and 7 days. Data are represented as mean ± SEM, and significance was determined by one-way ANOVA followed by the Tukey’s post hoc test. Il-1β (24 h: p = 0.0001; ***p < 0.001, 72 h: p < 0.0001; ***p < 0.001, 7 days: p = 0.0002; ***p < 0.001 CCI + Vehicle vs Sham, 24 h: p = 0.0113; #p < 0.05, 72 h: p = 0.0001; ###p < 0.001, 7 days: p = 0.0011; ##p < 0.01 CCI + VCE-004.8 vs CCI + Vehicle). Il-6 (24 h: p = 0.0004; ***p < 0.001, 72 h: p = 0.0001; ***p < 0.001, 7 days: p = 0.0040; **p < 0.01 CCI + Vehicle vs Sham, 24 h: p = 0.0211; #p < 0.05, 72 h: p < 0.0001; ###p < 0.001, 7 days: p = 0.0018; ##p < 0.01 CCI + VCE-004.8 vs CCI + Vehicle). Ccl2 (24 h and 72 h: p < 0.0001; ***p < 0.001, 7 days: p = 0.0008; ***p < 0.001 CCI + Vehicle vs Sham, 24 h: p = 0.0058; ##p < 0.01, 72 h: p < 0.0001; ###p < 0.001, 7 days: p = 0.0009; ###p < 0.001 CCI + VCE-004.8 vs CCI + Vehicle). Il-10 (72 h: p = 0.0018; **p < 0.01 CCI + VCE-004.8 vs Sham, p = 0.0449; #p < 0.05 CCI + VCE-004.8 vs CCI + Vehicle, 7 days: p = 0.0013; **p < 0.01 CCI + Vehicle vs Sham, p = 0.0004; ***p < 0.001 CCI + VCE-004.8 vs Sham)

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