Fig. 8

VCE-004.8 upregulates angiogenesis after TBI: endothelial cell proliferation. A Representative immunofluorescence images for CD31 and Ki67 expression in the pericontusional cortex at 24 h, 72 h and 7 days after the brain injury. Scale bar equivalent to 25 µm. B The quantification of Ki67⁺/CD31⁺ cells per area is represented as mean ± SEM, and significance was determined by one-way ANOVA followed by the Tukey’s post hoc test. 24 h: p = 0.0002; ###p < 0.001, 72 h and 7 days: p < 0.0001; ###p < 0.001 CCI + VCE-004.8 vs CCI + Vehicle