Fig. 5
From: Increased levels of a pro-inflammatory IgG receptor in the midbrain of people with schizophrenia
Blood vessels and small cells are IgG positive in the substantia nigra from certain schizophrenia cases and control subjects. Representative images of IgG targeting cells and blood vessels in the substantia nigra (SN) of schizophrenia cases (a, b) and control subjects (c). Dopamine neurons are indicated by black arrows (identified by the presence of neuromelanin). a IgG positivity surrounds cells with round nuclei (red arrowheads) adjacent and adhering to IgG positive blood vessels (black closed arrowheads). b Diffuse halo of IgG immunoreactivity surrounded IgG positive blood vessels. c Faint background staining can be seen in absence of distinctive IgG immunoreactive staining. d Immunoreactive staining was absent in no anti-human IgG secondary control slide. Images taken at ×20 magnification. Scale bars are 50 μm