Fig. 7
From: Increased levels of a pro-inflammatory IgG receptor in the midbrain of people with schizophrenia
IgG abundance and distribution in the SN is unchanged by either diagnosis or inflammatory biotype. When analysing immunoreactivity (mean gray value) of the IgG channel, there was no difference either a by diagnostic group or b when schizophrenia subjects were separated in low and high-inflammation biotypes. This was also true when the difference (Δ) in gray values between IgG and no-IgG sections for each individual was analysed (c, d). Additionally, there was no difference in the total area of high intensity IgG staining (which likely reflects blood vessel and cellular staining as opposed to parenchymal staining) between diagnostic (e) or inflammatory groups (f). When IgG staining was correlated to LogFcGR3A gene transcript abundance, a significant negative correlation was evident for the high-inflammation biotype schizophrenia group (g; r = 0.53, p = 0.01). OD; optical density. Mean ± SEM