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Fig. 3 | Journal of Neuroinflammation

Fig. 3

From: Drp1 activates ROS/HIF-1α/EZH2 and triggers mitochondrial fragmentation to deteriorate hypercalcemia-associated neuronal injury in mouse model of chronic kidney disease

Fig. 3

CKD-induced hypercalcemia mediates Drp1/Fis1 to promote mitochondrial fragmentation and aggravate nerve damage. CKD mice were treated with calcitonin alone or combined with overexpressed Drp1 (n = 6). A Ca2+ content in serum of CKD mice. B Ca2+ content in prefrontal cortical tissues of CKD mice. C Expression of Drp1 and Fis1 proteins in prefrontal cortical tissues of CKD mice detected by immunohistochemical staining. D The escape latency, the number of times entering the target quadrant, the time spent in the platform quadrant, and the total distance of action of CKD mice by Morris water maze test. EH MDA level (E), SOD activity (F), ATP level (G), and ROS level (H) in the prefrontal cortical tissues of CKD mice. I The mean mitochondria size in cerebral cortex of CKD mice. J Apoptosis in prefrontal cortical tissues of CKD mice detected by TUNEL staining. K Proportion of NeuN-positive cells in prefrontal cortical tissues of CKD mice detected by immunofluorescence staining. N = 6. *p < 0.05

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