Fig. 2
From: Chronic stress-induced depression requires the recruitment of peripheral Th17 cells into the brain
CRS leads to BBB disruption in the DLS and DMS. a Tissue dissection sites; b CRS increased fluorescein sodium leakage into the DLS and DMS; c the expression of TJs protein claudin-5 is significantly decreased in the DLS and DMS of rats exposed to CRS; d and e representative confocal images of the expression changes of claudin-5 in the BBB; f quantification of claudin-5 immunoreactivity in the DLS and DMS; g–i the expression changes in vascular permeability factors. The expression of VEGF and MMP-9, but not MMP-2, are increased in the DLS and DMS; scale bar, 25 μm. Data are expressed as mean ± SD, Student’s t-test, *p < 0.05, **p < 0.01, ***p < 0.001, compared with control