Fig. 5
From: Chronic stress-induced depression requires the recruitment of peripheral Th17 cells into the brain
Inhibiting CD4+ T-cell differentiation into pathogenic Th17 cells is effective in ameliorating CRS-induced depressive-like behaviour. a Chemical structure of SR1001; b experimental scheme of SR1001 treatment; compared to CRS group, rats showed increased sucrose consumption in SPT (c), decreased immobility in FST (d) and shorter latency to eat chow in NSFT (e) after SR1001 treatment; the expression levels of IL-6 in serum (f); IL-17 and IL-22 in serum (g) and dorsal striatum (h) were fully or partially reversed after SR1001 treatment. Data are expressed as mean ± SD, ANOVA followed with LSD post hoc, *p < 0.05, **p < 0.01, ***p < 0.001, compared with CRS group