Fig. 6From: Chronic stress-induced depression requires the recruitment of peripheral Th17 cells into the brainA schematic diagram illustrates the proposed mechanism. The recruitment of peripheral CD4+ Th17 cells into the CNS is closely associated with the development of CRS-induced depressive-like symptoms. Through a complex cascade of events, the peripheral immune response is propagated into the CNS through a leaky BBB, thereby progressively exacerbates neuroinflammation and disease symptomsBack to article page