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Fig. 6 | Journal of Neuroinflammation

Fig. 6

From: Chronic stress-induced depression requires the recruitment of peripheral Th17 cells into the brain

Fig. 6

A schematic diagram illustrates the proposed mechanism. The recruitment of peripheral CD4+ Th17 cells into the CNS is closely associated with the development of CRS-induced depressive-like symptoms. Through a complex cascade of events, the peripheral immune response is propagated into the CNS through a leaky BBB, thereby progressively exacerbates neuroinflammation and disease symptoms

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