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Fig. 5 | Journal of Neuroinflammation

Fig. 5

From: Glyphosate infiltrates the brain and increases pro-inflammatory cytokine TNFα: implications for neurodegenerative disorders

Fig. 5

Glyphosate exposure alters the brain transcriptome. A Volcano plot showing the differential expression analysis results after dosage regression. Genes in blue and red were downregulated and upregulated, respectively, after glyphosate exposure (adj-p < 0.05). B Volcano plots showing differential expression in individual cell class following deconvolution analysis. A: astrocytes; EC: endothelial cells; GB_N: GABAergic neurons; GL_N: glutamatergic Neurons; M: microglia; NoEnrichment: unclassified cell type; O: oligodendrocytes; OPC: oligodendrocyte progenitor cells. Colored dots represent dysregulated gene expression. C Boxplot of normalized counts for Plp1 showing significant dose-dependent upregulation (p adj. = 0.034). D Boxplot of normalized counts for Cntn2 showing significant dose-dependent upregulation (p adj. = 0.029). E Boxplot of normalized counts for Arhgef10 showing significant dose-dependent upregulation (p adj. = 0.010). F Boxplot of normalized counts for Abca2 showing significant dose-dependent upregulation (p adj. = 0.008)

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Journal of Neuroinflammation

ISSN: 1742-2094