Fig. 2From: Spotlight on pyroptosis: role in pathogenesis and therapeutic potential of ocular diseasesInflammasome-independent pathway of pyroptosis. YopJ expressed during Yersinia infection inhibits TGF-β-activated kinase 1 (TAK1) and induces caspase-8-related cleavage of GSDMD and GSDMC. Neutrophil elastase, porcine epidemic diarrhea virus, and cathepsin G cleave GSDMD. Caspase-8 acts upstream of caspase-3 through the Bax/Bak signaling, while caspase-3 mediates GSDME cleavage. GZMA and GZMB activate GSDMB and GSDME, respectively. Streptococcal pyrogenic exotoxin B (SpeB) could cleave GSDMA and trigger pyroptosisBack to article page