Fig. 11

Nilotinib reverses LPS-induced spatial memory impairment and cortical dendritic spine number in wild-type mice. a, b Y-maze and novel object recognition (NOR) tests were performed on days 7 and 8, respectively. Spontaneous alternations and number of total entries are represented in a, and object preference is shown in b (n = 8–11 mice/group). c, d After the behavior experiments, Golgi staining was performed, and dendritic spine number was measured in the cortical and hippocampal AO and BS regions (n = 25–26 neurons from 4 to 5 mice/group). *p < 0.05, **p < 0.01, ***p < 0.001. Scale bar = 10 μM