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Fig. 8 | Journal of Neuroinflammation

Fig. 8

From: Nilotinib modulates LPS-induced cognitive impairment and neuroinflammatory responses by regulating P38/STAT3 signaling

Fig. 8

Nilotinib decreases LPS-induced microglial activation/morphology and astrocyte morphology in the brain in wild-type mice. a, c Immunofluorescence staining of microglial or astrocyte expression in brain slices from wild-type mice injected with vehicle (5% DMSO, 10% PEG and 20% Tween 80 in deionized water) or nilotinib (20 mg/kg, i.p.) daily for 7 days followed by LPS (10 mg/kg, i.p.) or PBS on day 7. b, d Quantification of data in a and c (Iba-1, n = 15–22 brain slices from 3–4 mice/group; GFAP, n = 15–22 brain slices from 3 to 4 mice/group). *p < 0.05, **p < 0.01, ***p < 0.001. Scale bar = 100 μM

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