Fig. 5
MSC treatment reduced pathological protein deposition and promoted glucose metabolism after rmTBI. A–D Western blot for APP, Aβ1-42, p-Tau, Tau-5 was performed on day 28 after rmTBI. Protein expression was normalized to GAPDH and expressed as a fold change in sham. Data are expressed as mean ± SD (n = 6) and analyzed using one-way ANOVA with Tukey’s post hoc test (B) and one-way ANOVA with Dunnett’s T3 post hoc test (D). E–G Reconstructed S16-TAU PET/CT images and [18F] FDG PET/CT images of mice in the sham, vehicle, MSCs and Lip-1 groups (E). Bar graph showing maximum SUV values in different regions of the brain of mice, including the cortex and hippocampi. Data are expressed as mean ± SD (n = 3) and analyzed using one-way ANOVA with the LSD post hoc test (F, G). For vehicle group: **P < 0.01, and ***P < 0.001 vs sham group; for MSCs group: #P < 0.05, ##P < 0.01, and ###P < 0.001 vs vehicle group; for Lip-1 group: ##P < 0.01, ###P < 0.001 vs vehicle group