Fig. 3
From: Activation of peripheral TRPM8 mitigates ischemic stroke by topically applied menthol
Blocking TRPM8 activation increases cerebral infarction volume and worsens sensorimotor function after MCAO in the controls, mice treated with 16% menthol (ME) alone, AMTB plus ME, or lidocaine plus ME. A TTC staining of cerebral infarction volume. Scale = 5 mm. B Infarct volumes (mm3) assessed in ischemic brain tissue after 1 week MCAO. C Rotarod performance. D, E Adhesive testing showing contact times (D) and latency-to-removal times (E). The results are shown as the means ± SEM. *p < 0.05 vs water; #p < 0.05 vs ME alone. In each bar in B–E, the number of individuals of each group was shown within parentheses, and the symbols indicate the data of mice used in each study group