Fig. 6
From: Activation of peripheral TRPM8 mitigates ischemic stroke by topically applied menthol
Topically applied menthol (ME) to paws does not attenuate MCAO injury in Trpm8−/− mice. A TTC staining depicts the lesions 1 week after MCAO in Trpm8+/+ and Trpm8−/− mice. The scale bar represents 5 mm. B The individual lesion volumes for water-or menthol-treated Trpm8+/+ and Trpm8−/− mice are shown. C Rotarod performance of Trpm8+/+ and Trpm8−/− mice. All data are expressed as the means ± S.E.M. *p < 0.05 vs water-treated Trpm8+/+ mice; #p < 0.05 vs menthol-treated Trpm8+/+ mice. In each bar in B, C, the number of individuals of each group was shown within parentheses, and the symbols indicate the data of mice used in each study group