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Fig. 4 | Journal of Neuroinflammation

Fig. 4

From: Aprepitant attenuates NLRC4-dependent neuronal pyroptosis via NK1R/PKCδ pathway in a mouse model of intracerebral hemorrhage

Fig. 4

Effects of Aprepitant administration on neuronal degeneration and pyroptosis at 24 h post-ICH. A, B Representative images and quantitative analysis of Fluoro-Jade C (FJC) staining in the peri-hematomal area at 24 h after ICH. C, D Representative images and quantitative analysis of terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) staining in the peri-hematomal area at 24 h after ICH. E, F Representative images and quantitative analysis of cleaved caspase‐1 (C‐caspase‐1) positive neurons in the peri-hematomal area at 24 h after ICH. Data were represented as mean ± SD. * p < 0.05 vs sham; @ p < 0.05 vs ICH + vehicle. One-way ANOVA, Tukey test, n = 6/group. Scale bar = 200 µm

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Journal of Neuroinflammation

ISSN: 1742-2094