Fig. 3

The effect of ASK1 cKO on social and stress related activity after KA injection. The three-chamber sociability and social novelty preference test was used to determine whether epileptic mice had normal sociability A–C and normal social novelty recognition(D-F). A Representative track chart of the three-chamber sociability test was displayed. B Quantification of the interacting time with stranger 1. C Quantification of the proportion of time spent with stranger 1 or near empty cage. D Representative track chart of the three-chamber social novelty preference test. E Quantification of the time interacting with the stranger 2. F Quantification of proportion of time interacting with stranger 1 or stranger 2. All data are expressed as the mean ± SD. ***p < 0.001, **p < 0.01, and *p < 0.05, ns no significance, as indicated. n = 8 in the WT or cKO sham groups, n = 12 in WT KA or cKO KA groups, p values are based on the one way ANOVA test (B, E), Student’s t test (C, F)