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Fig. 6 | Journal of Neuroinflammation

Fig. 6

From: Conditional knockout of ASK1 in microglia/macrophages attenuates epileptic seizures and long-term neurobehavioural comorbidities by modulating the inflammatory responses of microglia/macrophages

Fig. 6

ASK1 cKO altered the mRNA expression of pro- and anti-inflammatory markers in the hippocampus(3d). A The mRNA levels of pro-inflammatory Mi/Mϕ specific marker (CD16, CD32). B The mRNA levels of released pro-inflammatory cytokines (TNFa, IL-1β and IL-6). C The mRNA levels of anti-inflammatory Mi/Mϕ specific markers (Arg-1, Ym1/2). D The mRNA levels of released anti-inflammatory cytokines (IL-13, TGFβ) and chemokines (CCL22). All data are expressed as the mean ± SD. ***p < 0.001, **p < 0.01, and *p < 0.05, ns no significance, as indicted. n = 4 in the WT sham or cKO sham groups, n = 7 in the WT KA group, n = 6 in the cKO KA group. p values are based on the one way ANOVA and Kruskal–Wallis ANOVA(A-D)

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Journal of Neuroinflammation

ISSN: 1742-2094