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Fig. 3 | Journal of Neuroinflammation

Fig. 3

From: Modulation of the proteoglycan receptor PTPσ promotes white matter integrity and functional recovery after intracerebral hemorrhage stroke in mice

Fig. 3

Inhibition of PTPσ by ISP promotes favourable inflammatory responses. a Left: protein was extracted from tissue surrounding the ICH shown in the white circle. Scale bar, 2.5 mm. Right: Iba-1 staining around the Hematoma at day 14 post-ICH. Scale bar, 200 µm. b Western blot analysis showed that ISP reduced Iba-1 protein expression in the presence of microglia relative to vehicle treatment at days 3, 7, and 14 post-ICH. c, d Western blot analysis showed a significant reduction in TNF-α and IL-1β protein expression in the ISP group related to the vehicle group at days 1, 3, 7, and 14 post-ICH. Data were normalized to β-tubulin protein expression. e–f Western blot analysis showed an increase of IL-10 and Arginase-1 protein expression in the ISP group related to the vehicle group at days 3, 5, 7, and 14 post-ICH. n = 3 per group. Data were analyzed by one-way ANOVA followed by Tukey’s multiple comparisons test, and expressed as mean ± SD. *p < 0.05, **p < 0.01, ***p < 0.001, ns not significant

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