Fig. 9
From: Sensory neuron dysfunction in orthotopic mouse models of colon cancer
Seahorse assay of DRG cells in the CT26 model. The mitochondrial function assay—performed on living lumbar DRGs of control and colon cancer bearing mice—reveals significant mitochondrial dysfunction 3 weeks after CT26 cell injection (similarly to the MC38 model). All values are normalized to mitochondrial-dependent respiration and the protein load. a, b Trend to reduced OCR and ECAR after addition of the uncoupler FCCP. c Deficits in mitochondrial function in CT26 versus vehicle-injected mice become statistically significant when corrected for non-mitochondrial oxygen consumption. *: p < 0.05; **: p < 0.01, two-tailed unpaired t test