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Fig. 6 | Journal of Neuroinflammation

Fig. 6

From: Hyperphosphorylated tau mediates neuronal death by inducing necroptosis and inflammation in Alzheimer’s disease

Fig. 6

Nec-1 s improves behavioral defects in an AD mouse model. A Body weight of mice 1 week after the last injection in the three groups (n = 8–9). B Kaplan–Meier survival analysis of three mouse groups injected with Nec-1 (6.25 mg/kg) or vehicle (n = 11 per group). C Percentage exploration in three mouse groups in the novel object recognition paradigm (n = 8–9 per group). D Nest-building test was scored after 24 h, immediately after equal amounts of cotton were placed in each cage and lights were turned off (n = 8–9 per group). E Hindlimb clasping scores of three mouse groups on performing the hindlimb clasping test. (n = 8–9 per group). Data are presented as mean ± standard error of the mean (SEM), and one-way ANOVA with Dunnett’s multiple comparisons test was used to analyze the statistical significance of the data

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