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Table 2 Plasma complement levels per clinical group

From: Elevated CSF and plasma complement proteins in genetic frontotemporal dementia: results from the GENFI study

 

Non-carriers

Presymptomatic carriers

Symptomatic carriers

p

C2

0.358 (0.274–0.532)

0.332 (0.274–0.431)

0.411 (0.319–0.548)

0.006*

C4b

9.97 (8.00–12.3)

9.92 (8.15–12.8)

10.8 (8.88–14.3)

0.913

C5

29.1 (21.6–35.8)

27.0 (21.7–35.2)

31.0 (25.1–38.3)

0.358

Factor D

3.57 (2.99–4.37)

3.46 (2.69–4.15)

4.19 (3.50–5.28)

0.481

MBL

2.44 (0.841–4.20)

2.01 (0.860–4.12)

1.71 (0.763–4.41)

0.710

Factor I

39.6 (32.9–46.6)

37.9 (32.8–45.2)

40.9 (35.0–47.0)

0.863

C1q

71.4 (64.5–81.2)

71.2 (60.6–80.1)

68.7 (62.2–76.2)

0.636

C3

44.8 (29.9–98.2)

39.9 (29.9–58.8)

45.5 (30.5–102)

0.047**

C4

293 (254–360)

297 (252–348)

294 (254–349)

0.577

Factor B

168 (147–211)

167 (146–205)

170 (143–202)

0.772

Factor H

250 (213–295)

250 (212–288)

254 (228–285)

0.849

  1. All concentrations are expressed as medians (interquartile range) in µg/ml. P-values are derived from quantile regression models with age and sex as covariates. MBL mannose-binding lectin. *Pairwise comparisons: symptomatic vs presymptomatic carriers: p = 0.028. **Pairwise comparisons: symptomatic vs presymptomatic carriers: p = 0.004