Brain microglia activation and peripheral adaptive immunity in Parkinson’s disease: a multimodal PET study

Table 2 Linear regressions between microglia activation, disease duration, UPDRS III, and dopaminergic disruption in PD

VOI	Side		Duration	Hoehn and Yahr stages	MDS-UPDRS III scores	¹⁸F-FP-DTBZ SUVR
Caudate	Ipsilateral	R	− 0.163	0.003	− 0.288	− 0.042
Caudate		P	0.480	0.990	0.206	0.862
Putamen		R	− 0.184	0.398	0.412	0.204
Putamen		P	0.424	0.074	0.063	0.389
Substantia nigra		R	0.007	− 0.206	− 0.403	0.148
Substantia nigra		P	0.975	0.370	0.070	0.533
Caudate	Contralateral	R	− 0.019	− 0.023	− 0.366	− 0.141
Caudate		P	0.935	0.920	0.103	0.553
Putamen		R	− 0.138	0.421	0.349	0.124
Putamen		P	0.551	0.058	0.121	0.603
Substantia nigra		R	− 0.194	0.017	− 0.400	0.187
Substantia nigra		P	0.399	0.940	0.072	0.430
Brainstem		R	0.269	− 0.140	− 0.452	0.688
Brainstem		P	0.238	0.544	0.040*	0.001*

R correlation coefficient, P p-value, MDS-UPDRS III MDS-Unified Parkinson’s Disease Rating Scale motor scores, SUVR standardized uptake value ratio
*P < 0.05

ISSN: 1742-2094