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Fig. 1 | Journal of Neuroinflammation

Fig. 1

From: The cytokine IL-27 reduces inflammation and protects photoreceptors in a mouse model of retinal degeneration

Fig. 1

IL-27 reduced pro-inflammatory markers. a Inflammatory protein analysis. Significantly lower levels of IL-18, Ccl22 and IL-12p70 proteins in retinas from mice injected with 20 ng IL-27 compared with saline in retinas obtained 3 days after injection (n = 4). b QPCR analysis demonstrated that intravitreal injections of 20 ng IL-27 reduced pro-inflammatory microglia markers Nos2 and Trem2 compared to saline injections in retinas obtained 7 days after injection at P25 (n = 3). c Quantification of Iba1 + microglia/macrophage cells in the outer nuclear layer demonstrated similar levels among treatments (n = 3)

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