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Fig. 1 | Journal of Neuroinflammation

Fig. 1

From: Comparative analysis of transcriptome remodeling in plaque-associated and plaque-distant microglia during amyloid-β pathology progression in mice

Fig. 1

Study design and validation of the approach. A Schematic representation of the study design. B Gene expression of cell-type markers for microglia, astrocytes, oligodendrocytes, neurons and peripheral immune cells in laser captured control microglia from CX3CR1+/eGFP mice (CM, black), plaque-distant microglia (PCM, grey) or plaque-associated microglia (PAM, light grey) from APP/PS1Tg/0:CX3CR1+/eGFP mice. Gene expression is normalized to housekeeping genes expressions and set at 1 in whole cortex homogenates. C Gene expression of immediate early genes in the microglial sub populations. Gene expression is normalized to housekeeping genes expression and set at 1 in whole cortex homogenates. D Principal component analysis (PCA) of gene expression in the different microglia samples, based on the 13,923 expressed genes

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Journal of Neuroinflammation

ISSN: 1742-2094