Skip to main content
Fig. 6 | Journal of Neuroinflammation

Fig. 6

From: Comparative analysis of transcriptome remodeling in plaque-associated and plaque-distant microglia during amyloid-β pathology progression in mice

Fig. 6

CLEC7a, CST7 and CYBB mRNA expression in the prefrontal cortex of AD patient and NCI subjects. A–C Changes in mRNA expression of CLEC7a (A), CST7 (B) and CYBB (C) were measured by qPCR in samples from the prefrontal cortex of AD and NCI subjects; D microglia detection (P2RY12 mRNA, green, reconstituted image), 6E10 staining for amyloid plaques (white) and CLEC7A mRNA expression (red) were combined on slices from BA9-10 of AD and NCI subjects. Moderate level of CLEC7A is observed in both plaque-associated and plaque-distant microglia of AD patients (representative image from a 83 years old female). Overall lower level of mRNA expression is observed in microglia from NCI subjects (representative image from a 43 years old male). Right panels show zoomed regions; plain white arrowheads point to CLEC7A-positive plaque-associated microglia and open arrowheads CLEC7A-positive plaque-distant microglia. Scale bar 30 µm

Back to article page

Journal of Neuroinflammation

ISSN: 1742-2094