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Fig. 1 | Journal of Neuroinflammation

Fig. 1

From: The associations between plasma soluble Trem1 and neurological diseases: a Mendelian randomization study

Fig. 1

The overall design of Mendelian randomization analysis in the present study. Assumption 1, the genetic variants are supposed to be strongly associated with the risk of interest; Assumption 2, the genetic variants should not be associated with any confounding factors; and Assumption 3, the genetic variants should affect the risk of the outcome only mediated by the exposures. AD, Alzheimer’ s Disease; ALS, amyotrophic lateral sclerosis; CES, cardioembolic stroke; IV, instrumental variable; LAS, large-artery atherosclerosis stroke; MR, Mendelian randomization; MS, multiple sclerosis; PD, Parkinson’s Disease; sTrem1, soluble triggering receptor expressed on myeloid cell 1; SVS, small-vessel stroke

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Journal of Neuroinflammation

ISSN: 1742-2094