Fig. 5

A schematic representation of sTrem1 function in AD. Ligands combine with mTrem1 on immune cells to induce the inflammatory responses and phagocytosis of Aβ. sTrem1 comes from the proteolytic cleavage of mTrem1 by metalloproteinases or from the translation of an alternative splicing of Trem1 mRNA. sTrem1 may perform as a decoy peptide to inhibit the binding of mTrem1 with the ligands. Subsequently, the clearance of Aβ gets inhibited, inducing the accumulation of the protein in brain. AD, Alzheimer’s disease; mTrem1: membrane triggering receptor expressed on myeloid cell 1; sTrem1: soluble triggering receptor expressed on myeloid cell 1