The associations between plasma soluble Trem1 and neurological diseases: a Mendelian randomization study

Table 1 Detailed information of the studies and datasets used for Mendelian randomization analysis

Phenotype	Sample size (cases/controls)	Population	Consortium	Year	Journal	References
Plasma sTrem1	3301	European	–	2018	Nature	Sun et al. [22]
Neurodegenerative disease
Alzheimer’s disease	21,982/41,944	European	IGAP	2019	Nat Genet	Kunkle et al. [23]
Parkinson’s disease	33,674/449,056	European	IPDGC	2019	Lancet Neurol	Nalls et al. [24]
Amyotrophic lateral sclerosis	20,806/59,804	European	AVS	2018	Neuron	Nicolas et al. [25]
Multiple sclerosis	47,429/68,374	European	IMSGC	2019	Science	Patsopoulos et al. [26]
Epilepsy
Epilepsy	15,212/29,677	Mixed	ILAE	2018	Nat Commun	Abou-Khalil et al. [27]
Generalized epilepsy	3769/29677	Mixed	ILAE	2018	Nat Commun	Abou-Khalil et al. [27]
Focal epilepsy	9671/29677	Mixed	ILAE	2018	Nat Commun	Abou-Khalil et al. [27]
Cerebrovascular diseases
Ischemic stroke	34,217/406111	European	MEGASTROKE	2018	Nat Genet	Malik et al. [28]
Large-artery atherosclerosis	4373/406,111	European	MEGASTROKE	2018	Nat Genet	Malik et al. [28]
Small-vessel	5386/192662	European	MEGASTROKE	2018	Nat Genet	Malik et al. [28]
Cardioembolic	7193/406111	European	MEGASTROKE	2018	Nat Genet	Malik et al. [28]
Nontraumatic intracranial hemorrhage	2794/203068	European	FinnGen	2021	–	–
Subarachnoid hemorrhage	1338/201230	European	FinnGen	2021	–	–
Migraine
Migraine with aura	3541/176107	European	FinnGen	2021	–	–
Migraine without aura, drug-induced	180/218612	European	FinnGen	2021	–	–
Migraine without aura and triptan purchases	3215/164098	European	FinnGen	2021	–	–

AVS: ALS Variant Server; IGAP: International Genomics of Alzheimer’s Project; ILAE: International League Against Epilepsy; IMSGC: International Multiple Sclerosis Genetics Consortium; IPDGC: International Parkinson’s Disease Genomics Consortium; sTrem1: soluble Triggering receptor expressed on myeloid cell 1

ISSN: 1742-2094