Table 3 Sensitivity analysis of the associations between plasma sTrem1 levels and neurological diseases

Neurodegenerative diseases

 Alzheimer’s disease

1.089 (1.027, 1.154)

1.064 (1.010, 1.212)

1.085 (0.986, 1.194)

1.039 (0.926, 1.166)

1.084 (1.021, 1.152)

0.004

0.033

0.120

0.526

0.020

 Parkinson’s disease

1.080 (1.006, 1.160)

1.026 (0.967, 1.089)

1.157 (1.046, 1.280)

0.963 (0.764, 1.214)

1.087 (1.012, 1.168)

0.030

0.401

0.013

0.755

0.035

 Amyotrophic lateral sclerosis

1.037 (0.985, 1.092)

1.034 (1.007, 1.062)

1.055 (0.977, 1.139)

0.998 (0.909, 1.095)

1.035 (0.980, 1.092)

0.167

0.021

0.189

0.961

0.235

Multiple sclerosis

0.997 (0.934, 1.065)

1.014 (0.953, 1.079)

1.029 (0.903, 1.174)

1.049 (0.902, 1.220)

1.000 (0.934, 1.072)

0.934

0.667

0.674

0.549

1.000

Epilepsy

 Epilepsy

1.039 (1.008, 1.070)

1.042 (1.019, 1.065)

1.022 (0.971, 1.076)

1.064 (0.997, 1.135)

1.039 (1.008, 1.073)

0.012

0.008

0.434

0.110

0.049

  Generalized epilepsy

1.060 (1.009, 1.114)

1.059 (1.036, 1.083)

1.072 (0.982, 1.170)

1.059 (0.965, 1.161)

1.060 (1.005, 1.117)

0.020

0.002

0.196

0.281

0.084

  Focal epilepsy

1.052 (1.015, 1.092)

1.050 (1.009, 1.092)

1.001 (0.942, 1.063)

1.133 (1.013, 1.267)

1.041 (1.005, 1.077)

0.006

0.049

0.984

0.080

0.074

Cerebrovascular diseases

 Ischemic stroke-all

1.012 (0.973, 1.054)

1.015 (0.985, 1.045)

1.016 (0.958, 1.077)

0.986 (0.906, 1.074)

1.013 (0.973, 1.054)

0.546

0.357

0.600

0.757

0.548

  Large-artery atherosclerosis

0.985 (0.893, 1.086)

1.016 (0.951, 1.085)

0.990 (0.855, 1.147)

0.994 (0.821, 1.204)

0.987 (0.889, 1.096)

0.765

0.652

0.897

0.952

0.807

  Small-vessel

0.977 (0.891, 1.072)

0.977 (0.888, 1.075)

0.958 (0.789, 1.162)

1.027 (0.848, 1.244)

0.981 (0.891, 1.081)

0.626

0.638

0.669

0.790

0.707

  Cardioembolic

0.986 (0.914, 1.064)

0.990 (0.922, 1.062)

1.005 (0.880, 1.147)

0.995 (0.857, 1.154)

0.987 (0.918, 1.062)

0.721

0.781

0.947

0.943

0.738

 Nontraumatic intracranial hemorrhage

1.094 (0.978, 1.223)

1.066 (0.984, 1.155)

1.100 (0.939, 1.288)

1.028 (0.840, 1.258)

1.089 (0.973, 1.218)

0.116

0.140

0.265

0.793

0.162

 Subarachnoid hemorrhage

1.036 (0.891, 1.203)

1.080 (0.960, 1.211)

1.041 (0.831, 1.306)

0.960 (0.715, 1.288)

1.036 (0.883, 1.216)

0.648

0.225

0.732

0.790

0.671

Migraine

 Migraine with aura

0.944 (0.858, 1.039)

0.988 (0.911, 1.072)

0.919 (0.806, 1.048)

1.049 (0.841, 1.308)

0.944 (0.854, 1.043)

0.242

0.781

0.228

0.679

0.272

 Migraine without aura, drug-induced

0.793 (0.524, 1.199)

0.893 (0.720, 1.108)

0.756 (0.432, 1.322)

1.467 (0.671, 3.206)

0.772 (0.519, 1.150)

0.272

0.320

0.342

0.351

0.221

 Migraine without aura and triptan purchases

0.978 (0.881, 1.085)

0.999 (0.944, 1.058)

1.020 (0.887, 1.173)

0.980 (0.800, 1.200)

0.973 (0.873, 1.086)

0.671

0.985

0.783

0.847

0.636