Fig.6

Serum soluble factor analysis including the OLINK™ target 48 cytokine panel. A: development of coagulation factors throughout IA treatment. Data are shown as mean ± SEM. B coagulation factors at discharge in MPS and IA patients (whiskers span from min to max). C: Determination of specific coagulation factors at discharge. D Analysis of immunoglobulin and complement levels at discharge. E, F OLINK multiplex cytokine analysis. Data are shown as volcano plots indicating the p-value of a Wilcoxon paired rank-sum test against the log2 fold change of cytokine levels at discharge compared to baseline (MPS: 26 patients; IA: 16 patients). Horizontal dashed lines indicate significance thresholds and vertical dashed lines indicate a fold-change exceeding ± 25% of baseline values. Tabular results are shown in Additional file 1: Table S2