Fig. 7

Selected cytokines are upregulated in CSOM. Cochlear selected cytokine expression was assessed via quantitative PCR with normalization to GAPDH and β-actin at 3 days, 7 days and 14 days, and fold-change was quantified relative to control cochlea. The pro-inflammatory cytokines interleukin-1β (IL-1β) and IL-6 displayed increased expression at 3 days compared to 14 days. The anti-inflammatory cytokine IL-10 displayed increased expression at 14 days compared to 3 days. The chemokines CCL-2 and CXCL-2 displayed increased expression at 14 days compared to 7 days and 3 days, respectively. TNF-α, CCL-3 and CXCL-1 remained unchanged in these time points. The mouse number is shown in brackets. The data represent mean ± SEM