Fig. 2

Captopril treatment ameliorates epilepsy-related memory impairment in rats. A The experiment diagram of NOR is shown. B, C Representative heat map of traveling track diagram around objects and quantification of discrimination index show captopril treatment significantly ameliorates the epilepsy-related cognitive function impairment. D A schematic diagram of Y-maze test is shown. E Quantification of spontaneous alteration rate in Y-maze test shows captopril treatment reverses the epilepsy-related deficits in spatial memory. F The mean escape latency to the hidden platform in the water maze as a short-term learning function of 4 training days shows no significant difference among the groups. n = 6 rats/group, two-way ANOVA followed by Dunnett’s post hoc test. G, H Representative swimming paths and quantification of time spent in the platform quadrant on day 5 (spatial probe test day) show captopril treatment significantly improves the epilepsy-impaired short-term memory. n = 6 rats/group, ^#p < 0.05, ^##p < 0.01, compared to control; *p < 0.05, **p < 0.01, compared to KA, one-way ANOVA followed by Tukey’s post hoc test. Data are presented as mean ± SE