Fig. 3

Captopril treatment reduces the KA-induced phagocytosis and inflammatory responses in the hippocampus. RNA-seq analysis was performed using the hippocampal tissues 9 weeks after the KA induction. Results were normalized to the control group. P-values were obtained by edgeR using an exact test through the negative binomial distribution. A The volcano plot is shown for gene expression in the hippocampus with significantly increased (red) or decreased (blue) expression (p < 0.05, |log2|> 1) compared between the control and KA group (left) or between the KA and KA + Cap group (right). B Hierarchical clustering was performed for all the significantly altered gene expression. Magenta indicates the number of up-regulated genes and blue indicates the number of down-regulated genes. C The number of the shared and distinct DEGs in the hippocampus in the KA and KA + Cap groups. D GO and KEGG analysis of the transcripts with the shared DEGs in the KA and KA + Cap groups are shown. E The STRING analysis of the interactions of 240 top-regulated genes recovered after captopril treatment is shown. n = 3 rats/group