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Fig. 2 | Journal of Neuroinflammation

Fig. 2

From: Genetic targeting or pharmacological inhibition of galectin-3 dampens microglia reactivity and delays retinal degeneration

Fig. 2

Galectin-3 deficiency reduces microglia migration in light-exposed retinas. A Light exposure regimen performed with Lgals-3 KO mice and corresponding WT littermates. B Representative images of Iba-1+ cells in naïve and light-exposed WT and Lgals-3 KO retinas at the indicated time points. Scale bar: 50 µm. ONL, outer nuclear layer and INL, inner nuclear layer. C Quantification of Iba-1+ cells in the ONL. n = 15 retinas from individual mice D, E Galectin-3 transcript levels in light-exposed retinas (D) and RPE/choroids (E) in WT mice calibrated to naïve tissue. n = 9 retinas or RPE/choroids from individual animals. Data show mean ± SEM. *P < 0.05; **P < 0.01 and ***P ≤ 0.001 by ordinary one-way ANOVA followed by Tukey’s multiple comparisons

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