Fig. 5

NAM administration attenuates PPI and cognitive deficits induced by MS. A The baseline startle response to an auditory-evoked startle stimulus of 120 dB is shown in the left panel. Effects of NAM administration (100 mg/kg) on PPI at different pre-pulse intensities in the right panel. B Effects of NAM administration on the novel object recognition assay in different groups. C Effects of NAM administration on the latency to the target hole in the Barnes maze test. ^&p < 0.05, ^&&p < 0.01 as compared to MS + Saline rats, ^#p < 0.05, ^##p < 0.05 as compared to MS + NAM rats. CON + Saline, n = 10; MS + Saline, n = 10; CON + NAM, n = 10; MS + NAM, n = 10. n.s. not significant; *p < 0.05 and **p < 0.01 as compared to controls. Data are represented as mean ± SEM