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Fig. 9 | Journal of Neuroinflammation

Fig. 9

From: Nicotinamide reverses deficits in puberty-born neurons and cognitive function after maternal separation

Fig. 9

A proposed schematic illustrating how NAM administration might attenuate cognitive impairment in schizophrenia through the NAD+/Sirt3 pathway. NAD+ deficits in brain tissue downregulate Sirt3 expression in microglia, followed by increased protein acetylation and redox abnormalities. Microglia are activated and neuroinflammation is enhanced, which would induce neuronal damage and result in cognitive deficits. NAM administration can reverse these changes

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Journal of Neuroinflammation

ISSN: 1742-2094