Fig. 7

IL-6 blockade prevents vasospasm and improves neurologic scores. Schematic of SAH model set-up (A). Vasospasm measurements with arrows showing areas of vasospasm (B). A significant decrease in MCA/ICA ratio seen after SAH (p < 0.001). This was mitigated by IL-6 blockade (p < 0.01) (C). Mice with SAH had worse modified Garcia scale scores (p < 0.001), but improvement was seen with IL-6 blockade (p < 0.01) (D). Percentage of right turns (indicating impaired left motor functioning) was seen on post-SAH day 1 (p < 0.001) with improvement with IL-6 blockade (p < 0.01) (E). This effect was maintained on post-SAH day 3 (p < 0.01) with continued IL-6 blockade benefit (p < 0.05) (F). By post-SAH 5, the SAH mice were returning towards baseline but still had significant difference (p < 0.05) with benefit from IL-6 blockade (p < 0.05) (G). Black scale bar = 100 μm. * = comparison to saline, # = comparison to SAH