Fig. 5

Deep phenotyping of splenic and CNS B cell subsets in WT and SLAMF7^−/− mice. A, B SLAMF7 expression level across CNS (A) and splenic (B) B cell subsets at steady state and during active EAE neuroinflammation in WT mice. C Frequency of various B cell subsets from total splenic B cells in WT and SLAMF7^−/− mice at steady state and during EAE. D Frequency of various B cell subsets from total CNS B cells in WT and SLAMF7^−/− mice at steady state and during EAE. E MHC-II expression on splenic immature plasma cells. F CD80 expression on splenic immature plasma cells. G CD43 expression on splenic immature plasma cells. H IgM expression on splenic immature plasma cells. Data in A–H representative of a single experiment. Groups in A, B compared with multiple unpaired two-way t-tests with a Holm–Sidak correction for multiple comparisons. Groups in C–H compared with a two-way ANOVA with Sidak’s test for multiple comparisons. FO, follicular; MZ, marginal zone; Bregs, regulatory B cells