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Fig. 4 | Journal of Neuroinflammation

Fig. 4

From: Pregabalin mitigates microglial activation and neuronal injury by inhibiting HMGB1 signaling pathway in radiation-induced brain injury

Fig. 4

Pregabalin rescued neuronal apoptosis and loss in the RIBI mice. A Representative images of TUNEL staining and quantification of TUNEL-positive cells in the cortex. B Representative images and quantification of Caspase 3/NeuN immunofluorescence staining in the cortex. C-F Representative immunofluorescent images and quantification of neuronal proportion in the cortex and hippocampus. Data were analyzed by one-way ANOVA followed by the Student’s t-test analysis. All other groups were compared with the indicated group. n = 4 mice per group and 2–3 slices per mouse for immunofluorescence staining. Data were presented as mean ± SEM, *p < 0.05, **p < 0.01, and ***p < 0.001

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