Fig. 8

Erbin alleviates neuronal damage and improves cognitive function by inhibiting IRE1α/Xbp1s pathway. A Western blot for PSD95, SYP, and SYN1 protein expressions in the hippocampus. B Cell viability of HT22 cells cultured in microglia CM was examined by CCK8. C Western blot for PSD95 and SYP protein expressions in microglia CM cultured HT22 cells. D-F Neuronal damage was measured by Nissl staining. Scale bar, 50 μm. G Traveled distance, H preference indices, I time spent in the target quadrant, J numbers of crossings through the platform, and K escapes latency was measured in each group (n = 10). L 7-day survival rate of mice was recorded after CLP. Data are representative of three independent experiments. *p < 0.05, **p < 0.01 vs. Sham group; ^#p < 0.05, ^##p < 0.01 vs. CLP group; ^&p < 0.05, ^&&p < 0.01 vs. Erbin^−/− + CLP group