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Fig. 4 | Journal of Neuroinflammation

Fig. 4

From: Injection of amyloid-β to lateral ventricle induces gut microbiota dysbiosis in association with inhibition of cholinergic anti-inflammatory pathways in Alzheimer’s disease

Fig. 4

1–42 i.c.v induced changes of colonic structure in mice. A, B Weight and weight gain among three groups at baseline, 2 and 4 weeks after surgery. C Colon length of mice in each group 4 weeks after surgery. D Feces production within 24 h in each group 4 weeks after surgery. E Intestinal transit in each group 4 weeks after surgery. F Levels of serum FITC-dextran in each group 4 weeks after surgery 90 min after oral gavage. G, I Immunofluorescence and quantification of ZO-1 in colon of each group. Scale bars, 500 μm. H, J Immunofluorescence and quantification of PGP9.5 positive neurons in colon of each group. Scale bars, 200 μm. KM Western blot and quantification of ZO-1 and CLDN5 in colon of each group. n = 6 per group. Data were presented as mean ± SEM. Statistics were analyzed using one-way analysis of variance (ANOVA) and followed by Fisher’s least significant difference (LSD) test.  P < 0.05, **P < 0.01, ns no statistical difference

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