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Table 1 Expression of P2X receptor genes in brain resident cells in humans and mice

From: Blocking P2X7 by intracerebroventricular injection of P2X7-specific nanobodies reduces stroke lesions

Cell class

Species

P2X1R

P2X2R

P2X3R

P2X4R

P2X5R

P2X6R

P2X7R

Panx1

All

Mice

0.332

0.511

1.216

19.836

1.051

3.929

7.355

29.659

Human

0.292

0.339

0.445

10.320

5.952

6.170

41.939

13.923

Non-Neuronal

Mice

2.397

0.000

1.514

46.330

0.524

7.071

80.562

6.860

Human

2.705

0.003

0.641

15.760

0.002

1.908

120.507

8.173

Endothelial

Mice

0.003

0.000

0.116

17.535

0.563

0.000

5.314

3.262

Human

45.215

0.000

0.000

3.565

0.000

0.000

0.067

2.641

Microglia/PVM

Mice

13.870

0.000

0.067

132.048

0.000

0.617

390.551

12.421

Human

26.250

0.000

0.074

92.659

0.000

0.054

226.445

16.611

Astrocytes

Mice

0.012

0.000

0.898

28.560

0.327

10.739

17.652

0.044

Human

0.176

0.000

1.042

11.586

0.002

0.507

26.116

1.883

Oligo-

dendrocytes

Mice

0.000

0.000

2.622

46.636

0.000

0.359

22.786

11.473

Human

1.076

0.009

0.812

12.157

0.003

2.621

189.904

7.268

OPC

Mice

5.271

0.000

9.382

20.593

5.435

0.000

122.913

56.927

Human

0.098

0.000

0.098

5.707

0.000

3.245

121.165

15.029

Excitatory

Neurons

Mice

0.369

0.008

1.331

23.817

0.993

5.603

4.603

25.911

Human

0.149

0.480

0.452

10.647

6.711

5.875

45.346

11.203

Inhibitory

Neurons

Mice

0.117

1.118

1.084

13.174

1.170

1.884

4.010

36.270

Human

0.119

0.052

0.383

8.268

5.328

7.877

15.680

22.188

  1. Expression data from the Allen Brain Atlas for mice [18] and humans [19] on P2X receptors and pannexin 1. P2X7 expression is mainly found on human and rodent microglia and perivascular macrophages (PVM). Data are given as the mean count per million (CPM). Other cells show substantially lower expression of P2X7. Although oligodendrocytes show high expression of P2X7 in humans, this cannot be transferred to rodents. Oligo precursor cells (OPC) show intermediate P2X7 expression in humans and rodents