Fig. 4

Interactions between the cGAS–STING pathway and ferroptosis. Loss of GPX4 function, either directly or indirectly, is currently thought to be the key event leading to the onset of ferroptosis. In addition, GPX4 is needed for activation of the cGAS–STING pathway. GPX4 deficiency enhances lipid peroxidation, which promotes STING carbonylation and inhibits its translocation from the ER to the Golgi complex