Fig. 7

LPS-induced ethidium bromide uptake is dependent on the activity and expression of Panx 1 in cultured Schwann cells. A, C Ethidium bromide fluorescence in Schwann cells increased after exposure to LPS (24 h, 100 ng/ml); however, this increase was suppressed by the Panx 1 inhibitors, CBX and probenecid (A), and Panx 1 siRNA (C). B, D Quantification of ethidium bromide fluorescence intensities and the effect of Panx 1 inhibitors (B) and siRNA (D). All data are mean ± SEM. ***p < 0.01, vs. the control group or Ctrl-siRNA group, ^###p < 0.001, vs. LPS treatment alone group. The data were analyzed by one-way ANOVA followed by Tukey’s multiple comparison test