Skip to main content
Fig. 3 | Journal of Neuroinflammation

Fig. 3

From: Alzheimer’s disease-related transcriptional sex differences in myeloid cells

Fig. 3

Sex differences in the transcriptomic profile of monocyte-derived macrophages from women (Flo) and men. A Bar chart showing the enrichment of IR-AD gene sets. A negative log fold change (logFC) denotes enrichment in Flo-MDMs whilst a positive logFC denotes enrichment in M-MDMs. Significantly enriched gene sets are shown in colour, with blue indicating enrichment in Flo-MDMs. B Volcano plot showing the number of significantly differently expressed Reactome and XiE (genes known to escape X-chromosome inactivation) gene sets between the M- and Flo-MDMs. Each dot represents one of the total 382 gene sets. C Dot plot showing a collection of significantly sexually differentially expressed gene sets (sDGS)  between M-MDMs and Flo-MDMs.  For plots B and C, p values were calculated via mixed-effects models with Benjamin-Hochberg multiple test corrections.

Back to article page