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Fig. 6 | Journal of Neuroinflammation

Fig. 6

From: Microglial–oligodendrocyte interactions in myelination and neurological function recovery after traumatic brain injury

Fig. 6

Post-TBI administration of selective NHE1 inhibitor HOE642 in C57BL/6 wild-type mice showed neuroprotection and enhanced oligodendrogenesis. a Contusion volume of Veh or HOE-treated brains at 3 days post-TBI by MAP2 staining. Data are mean ± SEM. N = 5–6. b Immunostaining of MAP2 and NeuN in the peri-lesion cortex of Veh or HOE-treated brains at 3 days post-TBI. Scale bar = 50 µm. c Representative images and quantification of Olig2 colocalized with NG2, Ki67, Caspase-3, and H3K9me3 in CC at 3 days post-TBI. Arrows: colocalized cells. Scale bar = 10 µm. Data are mean ± SEM. N = 3–4. *p < 0.05, ***p < 0.001, ****p < 0.0001

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